Exosomal RP5-977B1 revealed an AUC value of 0.8899 (P < 0.001) in distinguishing patients with NSCLC from the healthy and patients with pulmonary tuberculosis, while serum CEA and CYFRA21-1 shown an AUC = 0.7609 (P < 0.001) and 0.6703 (P = 0.0001), respectively (Fig. 3A, Table 1). Here, CEACAM5 is linked to pulmonary tuberculosis.