For example in T-B-NK + SCID patients, Gly35Val variant in RAG2 gene had been identified in 11 patients coming from three governorates from North Egypt, while the p.Thr215Ile variant and p.Arg229Gln had been detected together both in homozygous form in 6 patients mostly coming from upper Egypt. The gene discussed is RAG2; the disease is severe combined immunodeficiency.