AVP and angina pectoris: Balmelli et al. [22] found that high levels of copeptin measured at hospital arrival were associated with worse prognosis: higher hospital mortality and 1-year mortality, in their prospective study in patients presenting to the Emergency Department with symptoms suggestive of acute MI of less than 12 h; although, in this study, only 15.9% of patients were finally diagnoses of acute MI, being the other diagnoses unstable angina (14.0%), cardiac but noncoronary cause in 13.0%, noncardiac cause of chest pain in 48.4% and remained of unknown origin in 48.4% of patients included in the study.