CD8A and metabolic dysfunction-associated steatohepatitis: The characteristic disturbance in lipid metabolism associated with NASH contributed to the auto-aggression of IL-15-activated CD8+ T cells due to increased metabolic stimulation from mediators such as acetate and extracellular ATP signalling through purinergic P2RX7 receptors [116] that are known to be highly expressed by TRM [118, 119] (Fig. 1).