PIK3CA and acute myeloid leukemia: KEGG pathway analysis results based on the DAVID database (Figure 4B) and Cytoscape ClueGO (Figure 4C) showed that the predicted targets were mostly enriched in “neurotrophin signaling pathway,” “prolactin signaling pathway” and “acute myeloid leukemia.” Among the targets in these pathways, NRas, PIK3CA, and Akt3 were found to be participants in the most pathways.