Acetic acid and butyric acid displayed a strong negative correlation with biomarker of AKI, including kidney injury score, BUN, HAVCR1, LCN2, and creatinine, and indicators of fibrosis and inflammation, which are fibrosis index, F4/80, and Ly-6G/Ly-6C, yet showed a notable positive correlation with urine output and relative body weight of mice. The gene discussed is HAVCR1; the disease is acute kidney injury.