Given the dependency of NG neurons on BDNF signaling, and studies showing that Elp1 cKO neurons have impaired NGF retrograde transport and TrkA signaling (Abashidze et al., 2014; Naftelberg et al., 2016; Li et al., 2020), it will be interesting to investigate in future studies whether nodose neurons in FD die due to faulty TrkB retrograde signaling. The gene discussed is BDNF; the disease is Fabry disease.