We observed that lncRNA BACE1-AS was over-expressed in MPP+ stimulated SH-SY5Y cells, and miR-214-3p was under-expressed in SH-SY5Y cells, indicating that lncRNA BACE1-AS was involved in development of PD through targeting of miR-214-3p. The gene discussed is BACE1; the disease is Parkinson disease.