To explore whether higher levels of pro-angiogenic factors IL8, IL15 and GROα could be involved in altered capillary sprout formation in AT, rIL8, rGROα and rIL15, either alone or in combination, were added to ND-AT and T2D-AT explants in concentrations equal to the averages of those found in CM from T2D and ND myotubes ([T2D-IL8] = 3280 and [ND-IL8 = 2071 pg/mL; [GROα] = 4620 and 1859 pg/mL; and [IL15] = 1.07 and 0.6 pg/mL, respectively) [14]. This evidence concerns the gene CXCL1 and type 2 diabetes mellitus.