CCN4 and breast cancer: Similarly, we demonstrated that compared with the lipofectamine 6000-mediated siWISP1 transfection, the expression of WISP1 in breast cancer cells was further decreased after US-mediated delivery of siWISP1, and meanwhile the cell migration, invasion, and proliferation were further inhibited, indicating that US could enhance the transfection efficiency and promote the antitumor activity of siWISP1.