Based on the previous studies, WISP1 has been found to be high-expressed in a variety of tumors and is closely related to poor prognosis of tumor patients, including oral squamous cell carcinoma [17], esophageal squamous cell carcinoma [18], and pancreatic ductal adenocarcinoma [19], thus it can serves as a clinical marker for above cancers. This evidence concerns the gene CCN4 and neoplasm.