CXCR4 and obesity due to melanocortin 4 receptor deficiency: In order to confirm the association between hub genes and obesity, we obtained the expression levels of hub genes in adipose from Attie Lab. Results showed that the expression levels of PVALB, NPY, KIF11, FOXM1 and CXCR4 in adipose tissue of obese mice were higher than those of lean mice, which meant that hub genes after IER intervention were strongly correlated with obesity.