As shown in Fig. S1 (left panel), compared with those in FH rats, the contents of serum IL-2, IL-6, and IL-17A were significantly lower in FH-FH rats, while the levels of serum IL-4, IL-10, and IFN-γ in FH-FH rats were significantly higher in FH-FH rats (Wilcoxon test, adjusted P < 0.05). This evidence concerns the gene IL4 and familial hyperaldosteronism.