ERBB4 and amyotrophic lateral sclerosis: In other studies of the genetic spectrum and variability in ALS patients, researchers found several ERBB4 variants, such as p.Met322Lys (25), Glu69Val, Arg103His (26, 27), p.Gly1272Arg, p.His374Gln and p.Met1059Thr, and the p.Gly1272Arg variant was a probable pathogenic variant (28).