ACSL4 and brain ischemia: Li et al. (104) found that the deletion of NCOA4 significantly eliminated ferritin-mediated phagocytosis induced by cerebral ischemia-reperfusion in vivo and in vitro, down-regulated ACSL4 and 15-LOX2, promoted the expression of GPX4 activity to inhibit ferroptosis, and reduced ischemic brain injury.