Data show that HIF-1α up-regulates SLC7A11 and induces damage by binding to its promoter, while SLC7A11 gene knockout in mice inhibits brain injury induced by cerebral ischemia/reperfusion (CI/R) or oxygen-glucose deprivation/reoxygenation (OGD/R) in vivo and in vitro (54). Here, SLC7A11 is linked to Cerebral ischemia.