Li et al. (123) revealed for the first time that ferroptosis was involved in collagenase-induced intracerebral hemorrhage in mice, and found that the ferroptosis inhibitor ferrostatin-1 (Fer-1) reduced iron deposition in vivo and in vitro; down-regulated ROS, prostaglandin-peroxide synthase (PTGS2), and COX2; prevented hemoglobin-induced neuronal death; and lessened neurologic and memory impairment and brain atrophy caused by intracerebral hemorrhage, thus revealing a long-term brain-protective effect (124). This evidence concerns the gene PTGS2 and intracerebral hemorrhage.