HAMP and ischemic stroke: It has been found that hepcidin inhibits the release of iron by binding to ferroportin1 (FPN1) on cell membranes and induces the internalization and degradation of the protein, and the increase in serum hepcidin and iron concentration in patients with ischemic stroke indicates that hepcidin plays an important role in ischemic iron overload of the cerebrum (34).