GPX4 and intracerebral hemorrhage: In addition, Zhang et al. (89) observed that pyridoxal isonicotinoyl hydrazine (PIH) decreased iron accumulation, ROS production, and lipid peroxidation around hematomas; upregulated GPX4; inhibited pro-inflammatory polarization; down-regulated the expression of IL-1β and TNF; and improved the degree of neurologic impairment in mice after intracerebral hemorrhage.