Keuters et al. (85) demonstrated that ADA-409-052—as an effective ferroptotic inhibitor—can reduce lipid peroxidation, GSH depletion, and GPX4 inactivation, inhibit the pro-inflammatory activation of BV2 microglia, protect N2a neurons from inflammatory macrophage damage, down-regulate the expression of pro-inflammatory genes, shrink infarct volume, and mitigate edema in mouse models of stroke. Here, GPX4 is linked to Stroke.