As such, these results indicated that we can successfully establish a PPAR-related COAD prognosis model with certain applicability, among which NR1D1 (nuclear receptor subfamily 1 group D member 1), ILK (integrin-linked kinase), TNFRSF1A (the tumor necrosis factor receptor superfamily, member 1A), and REN (renin) can be effective prognostic factors of COAD patients. This evidence concerns the gene NR1D1 and colon adenocarcinoma.