As such, these results indicated that we can successfully establish a PPAR-related COAD prognosis model with certain applicability, among which NR1D1 (nuclear receptor subfamily 1 group D member 1), ILK (integrin-linked kinase), TNFRSF1A (the tumor necrosis factor receptor superfamily, member 1A), and REN (renin) can be effective prognostic factors of COAD patients. Here, TNFRSF1A is linked to colon adenocarcinoma.