TNR and Alzheimer disease: For different types of dementias specific correlations with neural proteoglycans have been reported: In AD patients the CSF and serum levels of brevican or neurocan were concurringly found to be unchanged as compared to non-demented controls and there was no correlation with the Abeta42/40 values but a significant correlation between brevican, neurocan, and the brevican-interacting ECM glycoprotein tenascin-R (rho = 0.68–0.77, p < 0.05) (Begcevic et al., 2018; Brinkmalm et al., 2018; Minta et al., 2019b,2021a; Jonesco et al., 2020).