M2d macrophages are induced by the costimulation of the adenosine A2 receptor and TLR, expressing levels of IL-10 as well as IL-12, and characterized by presenting properties of tumor-associated macrophages that carry out angiogenesis and tumor progression (Leibovich et al., 2002; Grinberg et al., 2009; Park et al., 2009; Colin et al., 2014; Arora et al., 2018; Wang et al., 2019; Anders et al., 2021). Here, IL10 is linked to neoplasm.