TRDMT1 and metabolic disease: The deletion of mouse tRNA methyltransferase (DNMT2) prevented the increase of m5C and m2G levels in sperm 30–40 nt RNA fractions and the alteration of tsRNA profiles that are induced by HFD, which further abolished sperm tsRNA-mediated transmission of HFD-induced metabolic disorders to offspring (Zhang et al., 2018a).