In some studies, dynamic expression of HspB4 and B5 was observed in a rat glaucoma model, with initial downregulation followed by upregulation (Steele et al., 2006; Miyara et al., 2008; Guo et al., 2010; Piri et al., 2013; Thanos et al., 2014; Park et al., 2019). The gene discussed is CRYAA; the disease is glaucoma.