We observe a negative relationship with CTLA4, HAVCR2, LAG3, and TIGIT in THYM, CTLA4 and PDCD1 in TCGT, CTLA4 in GBM, HAVCR2 in KIRP, and PDCD1 in UCS (all p values < 0.05, Figure 7A). This evidence concerns the gene LAG3 and glioblastoma.