Previous investigations in static cell monolayers using RT4 bladder papilloma cells suggest that Nrf2 upregulation enhances the expression of both epithelial and mesenchymal markers (e.g., E-cadherin and ZEB1) while Nrf2 downregulation results in the attenuation of both markers (Bocci et al., 2019b). The gene discussed is ZEB1; the disease is urothelial papilloma.