NOTCH1 and cancer: Furthermore, in order to overcome the limitations of using pharmacological methods such as sulforaphane, additional experimental models involving specific ways of perturbing one or multiple genes (i.e., gene editing techniques such as CRIPSR/Cas9), epistasis studies modulating Notch and the EMT network, and physiologically relevant invasion models should be performed to investigate the impact of the Nrf2-EMT-Notch1 network on cancer invasion.