We found that ATF3 could promote TBHP-induced NPC apoptosis, ferroptosis, and ROS production via activating c-CASP3 and inhibiting SLC7A11 and SOD2, suggesting ATF3 might mediate the mixed cell death FAoptosis consisting of ferroptosis and apoptosis. This evidence concerns the gene SLC7A11 and nasopharyngeal carcinoma.