Compared with non-cataract patients, the relative mRNA expressions of Nrf2, HO-1, and BVRA were all decreased in the anterior lens capsule of the age and gender-matched ARNC (P = 0.020, P = 0.008, P = 0.035, Figures 1(a)–1(c)). The gene discussed is NFE2L2; the disease is cataract.