RIPK3 and aortic aneurysm: For example, studies found that the expression of RIPK3 was significantly enhanced in elastase-induced or angiotensin II-challenged apolipoprotein E −/− mouse models of acute aortic aneurysm or dissection, and inhibition of RIPK3-mediated necroptosis could prevent aortic enlargement and acute aortic aneurysm or dissection formation.