Moreover, NLR Family Pyrin Domain Containing 3- (NLRP3-) caspase-1 inflammasome could directly cleave and degrade contractile proteins in VSMCs, and NLRP3 or caspase-1 deficiency in mice significantly reduced angiotensin II-induced AD formation [32, 33], indicating that pyroptosis in VSMCs contributes to the development of TAAD. Here, AGT is linked to Alzheimer disease.