GSDME and metastasis: As shown in Table 2, the decrease in GSDME expression was significantly correlated with RB clinical tumor node metastasis (cTNM) (P = 0.0288), regional lymph node (N stage) (P = 0.0431), and pathological tumor node metastasis (pTNM) (P = 0.0425); however, no significant association was found between GSDME expression and sex.