Furthermore, we observed several arm-level deletions of BC tumor suppressor genes and favorable BC prognostic genes in patients who failed to achieve pCR, including CDKN2C (35), EPS15 (36), etc. Of note, there were a considerable number of genes related to BC development and progression in the regions where deletions were identified, including CDKN2C, EPS15, CBL, etc. Their associations with pCR rate of NAC should be further investigated separately. Here, CDKN2C is linked to breast cancer.