Although the MFI of ICOS on total CD8 T cells was decreased (Figure S5E), the frequency of ICOS+ cells was unchanged (Figure S3C) and the frequency of CD40L+ and PD-1+GZMB+ cells among CD8 T cells was even significantly enhanced in HP on D1 (Figures S5J and S5K). This evidence concerns the gene ICOS and hyperplastic polyp.