Reduced expression of ZO-1 was also observed in patients with CRS with nasal polyps, asthmatic patients, eosinophilic esophagitis (EoE) and these impaired epithelial TJ function are considered to be part of the pathophysiology (De Benedetto et al., 2011; Salim & Söderholm, 2011; Xiao et al., 2011; Soyka et al., 2012; Katzka et al., 2014). The gene discussed is TJP1; the disease is eosinophilic esophagitis.