In addition to a role in killing tumor cells, neoadjuvant chemotherapy can also promote the transformation of tumor cells into normal breast cells, so as to gradually restore the expression of ER, HER-2, SATB1 and other indexes to the normal range17 However, it should be noted that the immune dysfunction caused by chemotherapy will also result in immunosuppression of patients and reduce the therapeutic effect. The gene discussed is ERBB2; the disease is neoplasm.