The area under the curve (AUC) for the serum APN and Hb ROC curves for the diagnosis of vascular cognitive impairment in patients with ischemic stroke were 0.768 (95% Cl: 0.652-0.881) and 0.782 (96% Cl: 0.672-0.884), respectively (Fig.1). This evidence concerns the gene GSTM1 and ischemic stroke.