In the cardiovascular system, myocardial cells, endothelial cells and smooth muscle cells all express Tweak or its ligand FN14 mRNA or mRNA synthesis products.25,26 In this study, the levels of sTREM-1, sCD163 and sTWEAK with different infection severity and cardiac function grades in the infection group, the non-infection group and the control group are investigated, and the results show that all three indicators could reflect the cardiac function grade of patients with CHF. The gene discussed is TNFSF12; the disease is congestive heart failure.