TNFRSF12A and infection: In the cardiovascular system, myocardial cells, endothelial cells and smooth muscle cells all express Tweak or its ligand FN14 mRNA or mRNA synthesis products.25,26 In this study, the levels of sTREM-1, sCD163 and sTWEAK with different infection severity and cardiac function grades in the infection group, the non-infection group and the control group are investigated, and the results show that all three indicators could reflect the cardiac function grade of patients with CHF.