It is mainly applied in the diagnosis of sepsis, postoperative fracture infection and abdominal cavity infection.6,7 Soluble CD163 (sCD163), a soluble form of scavenger receptor family CD163, mainly mediates anti-inflammatory and antioxidant reactions.8 The expression of soluble tumor necrosis factor-like weak apoptosis-inducing factor (sTWEAK) is regulated by sCD163. Here, CD163 is linked to Sepsis.