Therefore, it may be suggested that the MEFV gene mutations might not be a susceptibility factor for RA, however, they appear to be an aggravating factor for the severity of RA and consequently, patients with RA might be screened for MEFV gene mutations in countries where FMF is frequent, as found in our study and suggested in other studies [13, 18, 25, 31]. This evidence concerns the gene MEFV and rheumatoid arthritis.