KDM2A and neoplasm: As well as KDM2A and KDM2B, which have K3K36me2 and H3K4me3 as their substrate, where its deregulation is associated with increased proliferation of stem cells and tumor growth and metastasis (Harris et al., 2012; Wagner et al., 2013) among other processes such as cell proliferation and drug resistance, among others.