YTHDF2 and neurodegenerative disease: Yu et al. (2019) found that the expression of YTHDF2 in macrophages was upregulated after lipopolysaccharide stimulation and that knocking out YTHDF2 reduced the levels of pro-inflammatory factors. HNRNPC plays an important role in various cancers and neurodegenerative diseases such as Alzheimer’s disease (Geuens et al., 2016). Studies have suggested that HNRNPC dysfunction causes Parkinson’s disease through immune inflammation (Quan et al., 2021).