NPC1 and aortic atherosclerosis: In addition to that, NPC1 deficient mice can reconstitute with LDL receptor and accelerated aortic atherosclerosis was observed in the NPC1−/− macrophages (Zhang et al., 2008).Furthermore, NPC1 repression was found to invoke lipid accumulation in human macrophages exposed to environmental aryl hydrocarbons (Podechard et al., 2009).