In addition to that, NPC1 deficient mice can reconstitute with LDL receptor and accelerated aortic atherosclerosis was observed in the NPC1−/− macrophages (Zhang et al., 2008).Furthermore, NPC1 repression was found to invoke lipid accumulation in human macrophages exposed to environmental aryl hydrocarbons (Podechard et al., 2009). This evidence concerns the gene LDLR and aortic atherosclerosis.