PCSK9 and familial hyperaldosteronism: FH is caused by genetic variants associated with low-density lipoprotein (LDL) metabolism, such as the LDL receptor (LDLR), apolipoprotein B (APOB), proprotein convertase subtilisin/kexin type 9 (PCSK9), and LDLR adaptor protein 1 (LDLRAP1) (Mabuchi, 2017).