Importantly, in the mouse model of psoriasis induced by treatment with the toll-like receptor 7 (TLR7) agonist imiquimod (IMQ), knockdown of plexin B2 in mouse keratinocytes in vivo limited inflammation and epidermal infiltration by dermal γδ T cells, which are known to be a critical source of IL-17 and drive inflammation in this model [51]. Here, TLR7 is linked to psoriasis.