Based on this initial characterization of JAML-CXADR-mediated costimulation of tissue-resident γδ T cells and the known roles of γδ T cells in antitumor immunity, the importance of JAML-CXADR interactions for γδ T cell responses within the tumor microenvironment (TME) was investigated. The gene discussed is CXADR; the disease is neoplasm.