MOG and multiple sclerosis: For example, recently it was possible to resurrect a pathogenic autoantibody response against myelin oligodendrocyte glycoprotein from the paraffin-embedded brain tissue of a patient who died more than 50 years ago.31 Similarly, a comparison of global gene expression in archival brain tissue from cases with multiple sclerosis and other chronic CNS inflammatory diseases has provided evidence for oxidative injury as an important driving force of demyelination and neurodegeneration in multiple sclerosis lesions.21