ERBB2 and breast cancer: The overall collective data identified that these breast cancer subtypes have different histopathological and clinical behaviors and are associated with different age groups and ethnicities [4, 8, 9], such as TNBC and HER-2 positive subtypes which are notably common in younger and premenopausal women, more prevalent in African-American and Asian women, exhibiting more metastatic potential with high relapse rate [10–15].