Interestingly, ITGA5, which is also a classic EMT marker enriched on tumor-specific keratinocyte (TSK) subsets of metastatic cSCC (9) and upregulated in various cancers (63), showed a stepwise increase in expression from SES to PRI, to PRI+ to MET (Supplementary Image 4). This evidence concerns the gene ITGA5 and neoplasm.