CDK6 and adrenal cortex carcinoma: In previous research, overexpression of DNA damage and cell cycle–dependent proteins were observed to be associated with poor survival in 79 adrenocortical carcinoma patients and were accompanied by the significant up-regulation of genes involved in DNA damage and the regulation of cell cycle pathways; indeed, greater expression of CDK6 was associated with worse survival irrespective of age or sex (21).