AKT1 and early-onset autosomal dominant Alzheimer disease: From KEGG, 49 pathways were enriched and the top 10 were nitrogen metabolism, pathways in cancer, PI3K-Akt signaling pathway, ovarian steroidogenesis, progesterone-mediated oocyte maturation, insulin resistance, arachidonic acid metabolism, microRNAs in cancer, phospholipase D signaling pathway, and Alzheimer’s disease; the top 20 enriched terms are presented in Table 4.