Consistent with in vitro findings, PRSS3 deletion favored xenograft tumor growth formed by Huh7 cells, with a significant augmentation by re-expression of PRSS3-V2 (PRSS3KO+V2), whereas re-expressing either PRSS3-V1 or PRSS3-V3 (PRSS3KO+V1/3) in the cells caused a marked inhibitory effect on xenograft tumor growth in contrast to a minimal role of PRSS3KO+V4 (Figure 5F). Here, PRSS3 is linked to neoplasm.