PRSS3 and hepatocellular carcinoma: Functional classification and experimental dissection of PRSS3-SVs and their response to 5-aza-CR treatment distinct between PRSS3Low and PRSS3High HCC cells (such as Huh7 versus HepG2 cells) may be used as an experimental model for studying PRSS3 splicing-mediated functional heterogeneity during hepatocarcinogenesis.