PRSS3 and cancer: This is in line with our previous observations on PRSS3/TRY-4 (36) and may explain some but not all cases of a similar phenotype with well-differentiated and/or low metastatic potential appearing in either PRSS3Low (e.g., HepG2 and SK-Hep1 cells) or PRSS3High (Huh7 cells) live cancer cell lines or a dual role of PRSS3 contradictorily shown in carcinogenesis.