In addition to a heatmap visualizing the differential expression of the hub genes (Figure S6C), Figure S6D shows significant upregulation of F2RL1, SMPDL3B, DUOX2, SLC43A3, GLUL and NKD1, but upregulation of TMEM45A and VNN1 in HCC tissues compared with normal human live tissues. The gene discussed is SMPDL3B; the disease is hepatocellular carcinoma.