PRSS3 and hepatocellular carcinoma: The CpG site methylation in the PRSS3 promoter region from -89 bp (CpG site 5) to 785 bp (CpG site E) to the TSS of PRSS3-V1/3 associated with the expression of PRSS3 transcripts suggests an epigenetic promoter contribution to divergent expression of PRSS3 transcripts in HCC (Figure 3A).