Kyoto Encyclopedia of Genes and Genomes (KEGG) pathway enrichment analysis indicated that these cancer-associated genes may be involved in the cell cycle and senescence through the PRSS3-V1-associated p53 signaling pathway, or via the PI3K-Akt pathway in association with PRSS3-V2/PRSS3, due to their corresponding pathways with more parallel lines (Figure S6G). Here, TP53 is linked to cancer.