The pathological examination after liver biopsy on 7 June 2017, confirmed metastatic breast carcinoma; IHC detected ER (90%+), PR (75%+), HER2 (1+), Ki-67 (about 30%+), FISH (non-amplification) (Figures 1E–H), CK7 (+), E-cadherin (+), GATA-3 (+), hepatocyte (−), CD3 (vessel+), GCDFP15 (+), and mammaglobin (+), with the diagnosis of right breast cancer recurrence (rT0N0M1, stage IV, lung and liver metastases). The gene discussed is ERBB2; the disease is breast carcinoma.