After an average follow-up of 62 months, it was also found that RAS was not a related factor for the primary outcome (all-cause death, peripheral vascular reperfusion treatment, and amputation) and secondary outcome (all-cause death, MI, stroke, and coronary or carotid reperfusion therapy), while age, insulin application, and severe limb ischemia were risk factors for all-cause mortality (16). The gene discussed is INS; the disease is Stroke.