Table 8 listed the top 20 keywords with the strongest citation bursts and sorted them by their strength. The top five hotspots were: tumor suppressor gene (10.38), BHD gene (8.52), kidney neoplasia (8.44), folliculin (8.16), acrochordon (7.56). Besides, keywords such as “management”, “tumor suppressor”, “flcn”, “spectrum”, “diagnosis” turned up constantly during the past 5 years (Table 9). The gene discussed is FLCN; the disease is Renal neoplasm.