For instance, TCF4, known as immunoglobulin transcription factor 2 (ITF-2; E2-2; SEF-2), contributes to the development of lymphoid (79) and mature plasmacytoid dendritic cells (pDCs), including Pitt-Hopkins syndrome caused by E2-2 haploinsufficiency (80) and the tumor-suppressive effect in SHH medulloblastoma (81). Here, TCF4 is linked to neoplasm.