Correlation analysis of KCDEGs with various fractions in TME revealed all these six KCDEGs (TFPI, TCF4, CDK14, SYNPO2, GJA1, and CPXM1) positively correlated with stroma score, endothelial cells, and fibroblasts (Figure 6A), which can be promisingly accountable for tumor progress and prognosis of melanoma patients. The gene discussed is SYNPO2; the disease is melanoma.