In this study, we found that malnourished patients had a significantly lower BMI in total, non-surgical, and surgical GIST inpatients (P < 0.001), a significantly lower level of serum albumin in total and non-surgical GIST inpatients (P < 0.001), and a significantly longer length of hospital stay in non-surgical GIST inpatients (P < 0.001) as compared with well-nourished patients. This evidence concerns the gene ALB and gastrointestinal stromal tumor.