Eventually, a four-gene (karyopherin subunit alpha 2(KPNA2), suppressor of cytokine signaling 2(SOCS2), GTP-binding protein 4(GTPBP4), and chromobox 2(CBX2)) signature model was constructed by multivariate analysis showing that they were independent prognostic factors for liver cancer (Table 3). The gene discussed is CBX2; the disease is liver cancer.