Besides, ToPP also includes the high frequently mutated gene lists in the ten canonical pathways which are, cell cycle, Hippo, Myc, Notch, Nrf2, PI-3-Kinase/Akt, RTK-RAS, TGFβ signaling, p53, and beta-catenin/Wnt (Sanchez-Vega et al., 2018), and it can facilitate users to explore how the alterations (copy-number alterations, mutations, fusions, or epigenetic silencing) of genes in these pathways impact prognosis in different tumor types. Here, TP53 is linked to neoplasm.