Eventually, a four-gene (karyopherin subunit alpha 2(KPNA2), suppressor of cytokine signaling 2(SOCS2), GTP-binding protein 4(GTPBP4), and chromobox 2(CBX2)) signature model was constructed by multivariate analysis showing that they were independent prognostic factors for liver cancer (Table 3). This evidence concerns the gene SOCS2 and liver cancer.