Firstly, we selected univariate analysis function in ToPP to screen out the top 10 genes (KPNA2, G6PD, SFPQ, SOCS2, EZH2, RAMP3, UCK2, GTPBP4, CBX2, and LIMS2) which are most relevant to the prognosis (OS) of liver cancer in gene expression level (Table S3). The gene discussed is SOCS2; the disease is liver cancer.