SGCB and heart failure: Rüdebusch et al. (2020) also demonstrated that sGC stimulation has protective effects associated with improved gene expressions in mice heart failure model induced by pressure overload (Rüdebusch et al., 2020) and interestingly we have recently reported that this sGC protective effects are independent of estrogen status in rodent pressure-overload model (Nobuaki et al., 2020).