In the studies on chemokine-mediated macrophages, cellular CXCL8 was the first chemokines found to be associated with TC, and cell lines from PTC and ATC were found to contain high levels of CXCL8 and TAMs, leading to tumor proliferation and metastasis (Kobawala et al., 2011). This evidence concerns the gene CXCL8 and neoplasm.