M1-TAMs play a key role in killing tumor cells by producing reactive oxygen/nitrogen species (ROS/RNS) and pro-inflammatory cytokines such as IL-1β, IL-6, and TNF-α, and thus M1-TAMs are macrophages with anti-tumor effects (Jeannin et al., 2018; Chen et al., 2019). This evidence concerns the gene TNF and neoplasm.